By Lori Burrows, McMaster University;
André O. Hudson, Rochester Institute of Technology;
Fidelma Fitzpatrick, RCSI University of Medicine and Health Sciences;
Juliana Côrrea, Escola de Administração de Empresas de São Paulo da Fundação Getúlio Vargas (FGV/EAESP);
Raúl Rivas González, Universidad de Salamanca;
Roy Robins-Browne, the University of Melbourne; and
Yori Yuliandra, Universitas Andalas

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Almost since antibiotics were first discovered, we’ve been aware bacteria can learn how to overcome these medicines, a phenomenon known as antimicrobial resistance.

The World Health Organization says we’re currently losing to the bugs, with resistance increasing and too few new antibiotics in the pipeline.

We wanted to know whether experts around the world think we will still have effective antibiotics in 50 years. Seven out of seven experts said yes.

Lori Burrows | Biochemist, McMaster University

Yes! Antibiotics are a crucial component of modern medicine, and we can’t afford to lose them. Despite the rise of resistance in important pathogens (bugs), and the substantial decrease in new drugs in development, we have multiple tools at our disposal to protect antibiotics. Stewardship – the principle of using antibiotics only when absolutely necessary – is key to maintaining the usefulness of current antibiotics and preventing resistance to new drugs from arising. New diagnostics, such as the rapid tests that became widely available during the pandemic, can inform stewardship efforts, reducing inappropriate antibiotic use for viral diseases. Finally, researchers continue to find creative ways, including the use of powerful artificial intelligence approaches, to identify antimicrobial compounds with new targets or new modes of action. Other promising tactics include using viruses that naturally kill bacteria, stimulating the host’s immune system to fight the bacteria, or combining existing antibiotics with molecules that can enhance antibiotic activity by, for example, increasing uptake or blocking resistance.

André Hudson | Biochemist, United States

Yes. The real question is not whether we will have antibiotics 50 years from now, but what form of antibiotics will be used. Most antibiotics we use today are modelled after natural products isolated from organisms such as fungi and plants. The use of AI, machine learning, and other computational tools to help design novel, unnatural compounds that can circumvent the evolution of antibiotic resistance are only in the very early stages of development. Many of the traditional medicines such as penicillins and other common antibiotics of today which are already waning in efficacy, will probably be of very little use in 50 years. Over time, with the aid of new technology, I predict we will have new medicines to fight bacterial infections.

Roy Robins-Browne | Microbiologist – Australia

Yes, we will have antibiotics (by which I mean antimicrobial drugs), because people will still get infections despite advances in immunisation and other forms of prevention. Having said this, drugs of the future will be quite different from those we use today, which will have become obsolete well within the next 50 years. The new drugs will have a narrow spectrum, meaning they will be targeted directly at the specific cause of the infection, which we will determine by using rapid, point-of-care diagnostic tests, similar to the RATS we currently use to diagnose COVID. Antimicrobials of the future won’t kill bacteria or limit their growth, because this encourages the development of resistance. Instead, they will limit the ability of the bacteria to cause disease or evade our immune systems.

Raúl Rivas González | Microbiologist – Spain

Yes, but not without effort. Currently, antimicrobial resistance is a leading cause of death globally, and will continue to rise. But in my opinion, there will still be useful antibiotics to combat bacterial infections within 50 years. To achieve this, innovation and investment is required. Artificial intelligence may even be able to help. An example is the compound “RS102895”, which eliminates the multi-resistant superbug Acinetobacter baumannii. This was identified through a machine learning algorithm. The future of antibiotics requires substantial changes in the search for new active molecules and in the design of therapies that can eliminate bacteria without developing resistance. We are on the right path. An example is the discovery of clovibactin, recently isolated from uncultured soil bacteria. Clovibactin effectively kills antibiotic-resistant gram-positive bacteria without generating detectable resistance. Future antimicrobial therapy may consist of new antibiotics, viruses that kill bacteria, specific antibodies, drugs that counter antibiotic resistance, and other new technology.

Juliana Côrrea | Public health expert – Brasil

Yes. However, available data suggest that without a shift in the political agenda towards the control and prevention of antimicrobial resistance, several antibiotics will have lost their utility. The problem of bacterial resistance is not new and the risk of antibiotics becoming ineffective in the face of the evolutionary capacity of bacteria is one of the main problems facing global health. The creation of policies to promote the appropriate use of this resource has not progressed at the same speed as inappropriate use in human and animal health and in agricultural production. The factors that impact antibiotic use are complex and vary according to local contexts. The response to the problem goes far beyond controlling use at the individual level. We must recognise the social, political, and economic dimensions in proposing more effective governance.

Yori Yuliandra | Pharmacist – Indonesia

Yes. Despite their reduced efficacy over time, antibiotics continue to be produced every year. Researchers are tirelessly working to develop new and more effective antibiotics. And researchers are actively exploring combinations of antibiotics to enhance their efficacy. While antimicrobial resistance is rising, researchers have been making remarkable progress in addressing this issue. They have developed innovative antibiotic classes such as FtsZ inhibitors which can inhibit cell division, a process necessary for bacteria to multiply. Clinical trials are currently taking place.

A deeper understanding of the molecular aspects of bacterial resistance has led to the discovery of new treatment strategies, such as the inhibition of key enzymes that play a pivotal role in bugs becoming resistant. And advances in computer technology have greatly accelerated drug discovery and development efforts, offering hope for the rapid discovery of new antibiotics and treatment strategies.

Lori L. Burrows, Professor of Biochemistry and Biomedical Sciences, McMaster University; André O. Hudson, Dean of the College of Science, Professor of Biochemistry, Rochester Institute of Technology; Fidelma Fitzpatrick, Consultant Microbiologist, Beaumont Hospital, Dublin, Ireland and Professor and Head of Department, Clinical Microbiology, RCSI University of Medicine and Health Sciences; Juliana Côrrea, Pesquisadora de pós-doutorado em saúde pública, Escola de Administração de Empresas de São Paulo da Fundação Getúlio Vargas (FGV/EAESP);  Raúl Rivas González, Catedrático de Microbiología. Miembro de la Sociedad Española de Microbiología., Universidad de Salamanca; Roy Robins-Browne, Honorary Professorial Fellow, medical microbiology, The University of Melbourne, and Yori Yuliandra, Associate Professor of Pharmaceutical Sciences, Universitas Andalas

This article is republished from The Conversation under a Creative Commons license. Read the original article.