Bacteria potentially involved in the development of Type 2 diabetes

Fernando F. Anhê is a postdoctoral research fellow in the Jonathan Schertzer lab at McMaster University. Photo by Tina Depko.

Bacteria may be involved in the development of Type 2 diabetes, according to a study published today in Nature Metabolism by researchers from McMaster University, Université Laval and the Québec Heart and Lung Institute.

The authors found that the blood, liver, and certain abdominal fat deposits in diabetics have a different bacterial signature than in non-diabetics.

The researchers demonstrated this using blood and tissue samples from 40 patients suffering from severe obesity taken during bariatric surgery. Half of the participants suffered from Type 2 diabetes, while the other subjects had normal blood glucose levels.

The researchers identified the bacterial genetic material in each of the tissues sampled, which came from the liver and three abdominal fat deposits. Based on the Type of bacteria present and their relative abundance, the researchers were able to determine the bacterial signature for each tissue.

Their analysis revealed that the bacterial signature in diabetics was not the same as in non-diabetics. It also showed that the total number of bacteria varied from one tissue to another, and was highest in the liver and the greater omentum (a fatty tissue connecting the stomach and the transverse colon), two areas that play an important role in metabolic regulation.

“Our findings suggest that in people suffering from severe obesity, bacteria or fragments of bacteria are associated with the development of Type 2 diabetes,” said the lead author André Marette, professor at Université Laval’s Faculty of Medicine and researcher at the Québec Heart and Lung Institute research centre.

According to the study, the bacterial genetic material detected in the tissues most likely comes from the intestine.

“We know that the intestinal barrier is more permeable in obese patients,” said Marette. “Our hypothesis is that living bacteria and bacterial fragments cross this barrier and set off an inflammatory process that ultimately prevents insulin from doing its job, which is to regulate blood glucose levels by acting on metabolic tissues.”

Fernando F. Anhê is first author on the paper and a postdoctoral research fellow in the Jonathan Schertzer lab in the Department of Biochemistry and Biomedical Sciences, and the Farncombe Family Digestive Health Research Institute.

Anhê added: “Location, location location…Beyond knowing the names of bacteria, their location is key to understanding how gut microbes influence host metabolism.”

The study was funded by the Canadian Institutes of Health Research.

Related Stories